| Colin Farrell | Detective Ray Velcoro |
| Rachel McAdams | Detective Ani Bezzerides |
| Taylor Kitsch | Officer Paul Woodrugh |
| Kelly Reilly | Jordan Semyon |
| Vince Vaughn | Frank Semyon |
| Ritchie Coster | Mayor Austin Chessani |
| Vinicius Zorin-Machado | Tony Chessani
(as Vinicius Machado) |
| Fred Ward | Eddie Velcoro |
| Christopher James Baker | Blake Churchman |
| W. Earl Brown | Detective Teague Dixon |
| Alex Fernandez | James O'Neal |
| James Frain | Lieutenant Kevin Burris |
| Michael Hyatt | Katherine Davis |
| Michael Irby | Detective Elvis Ilinca |
| Afemo Omilami | Police Chief Holloway |
| Pedro Miguel Arce | Danny Santos |
| Gabriel Luna | Miguel Gilb |
| Chris Kerson | Nails |
| Andy Mackenzie | Ivar |
| Yara Martinez | Felicia |
| Timothy V. Murphy | Osip Agronov |
| Abigail Spencer | Gena Brune |
| Christian Campbell | Richard Brune |
| Jake La Botz | Conway Twitty |
| Agnes Albright | Veronica Chessani
(as Agnes Olech) |
| Emily Rios | Betty Chessani |
| Weronika Rosati | Agnes |
| Chet Grissom | Bart Sallis |
| Courtney Halverson | Erica Jonson |
| Roberto Medina | Dr. Burke |
| Alex Rich | Tyler |
| Sol Landerman | Michael Bulgari
(as Solomon Shiv) |
| Alain Uy | Ernst Bodine |
| Troy Vincent | Dan Czarn |
| Philip Moon | Ashley Daison |
| Michael Edwin | Tony Transpo |
| Luke Edwards | Lenny Tyler |
| Joey Jennings | Colter |
| Riley Smith | Steve Mercer |
| Carlos Ayala | Constantine |
| Chez'Ney Hadley | Hooker |
| Ana Mercedes | Mrs. Peru |
| J. Francisco Rodriguez | Tommy Peru |
| Keir Thirus | Vinci PD |
| Eltony Williams | Fregredo |
| Marc Abbink | Spectator
(uncredited) |
| Ronnie Gene Blevins | Stan
(uncredited) |
| Nancy DeMars | 1st A.D.
(uncredited) |
| Shannon Garnett | Santos Posse
(uncredited) |
| Tina Grimm | Club Dancer
(uncredited) |
| Ben Guenther | Race Spectator
(uncredited) |
| Dwayne Marion Johnson | Bouncer
(uncredited) |
| Abraham Luna | Santos Posse
(uncredited) |
| Pat-Ric McCaffery | Spectator Dude /
Gambit Fan
(uncredited) |
| Alessandro Pulisci | Race Fan
(uncredited) |
| Keith A. Somers | Vault Attendant
(uncredited) |
| Bruce M. Stockert | Race Spectator
(uncredited) |