| Dominic West | Det. James 'Jimmy' McNulty |
| Reg E. Cathey | Norman Wilson |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Aidan Gillen | Mayor Thomas 'Tommy' Carcetti |
| Clark Johnson | City Editor Augustus 'Gus' Haynes |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Tom McCarthy | Scott Templeton |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Col. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Thomas 'Herc' Hauk |
| Michael Kenneth Williams | Omar Little |
| Gbenga Akinnagbe | Chris Partlow |
| Jamie Hector | Marlo Stanfield |
| Neal Huff | Chief of Staff Michael Steintorf |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Corey Parker Robinson | Det. Leander Sydnor |
| Tristan Mack Wilds | Michael Lee |
| Michael Kostroff | Maurice 'Maury' Levy |
| Michelle Paress | Alma Gutierrez |
| Isiah Whitlock Jr. | State Sen. R. Clayton 'Clay' Davis |
| Frankie Faison | Commissioner Ervin H. Burrell |
| Amy Ryan | Off. Beatrice 'Beadie' Russell |
| Marlyne Barrett | Council President Nerese Campbell |
| Robert F. Chew | Joseph 'Proposition Joe' Stewart |
| Delaney Williams | Sgt. Jay Landsman |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Duane Chandler Rawlings | Nathaniel 'Hungry Man' Manns |
| Troj Strickland | Ricardo 'Fat Face Rick' Hendrix |
| Anwan Glover | Slim Charles |
| David Costabile | Managing Editor Thomas Klebanow |
| Sam Freed | Executive Editor James C. Whiting III |
| Dion Graham | State's Attorney Rupert Bond |
| Bruce Kirkpatrick | Roger Twigg |
| Jay Landsman | Maj. Dennis Mello |
| Edward T. Norris | Det. Edward Norris |
| Method Man | Melvin 'Cheese' Wagstaff |
| Joe Urla | U.S. Attorney for the District of Maryland |
| Gregory L. Williams | Det. Michael Crutchfield |
| William F. Zorzi | Bill Zorzi |
| Bobby J. Brown | Off. Bobby Brown |
| Benjamin Busch | Off. Anthony Colicchio |
| Rick Otto | Off. Kenneth Dozerman |
| Ryan Sands | Off. Lloyd 'Truck' Garrick |
| Ron Tucker | Western District Officer |
| Thomas J. McCarthy | State Editor Tim Phelps |
| Donald Neal | Rewrite Man Jay Spry |
| Robert Poletick | Metro Editor Steven Luxenberg |
| Kara Lee Duncan | Regional Affairs Editor Rebecca Corbett |
| Todd Scofield | Jeff Price |
| Eisa Davis | Bubbles' Sister |
| Gil Deeble | Hucklebuck |
| Edward Bernard Green Jr. | Spider |
| Dante Painter Jr. | DeShawn |
| Corbin Smith | Monell |
| Peter Linari | Pete the Bartender |
| Laura Lippman | Self |
| Michael Olesker | Self |
| Gene Terinoni | Lt. Jimmy Asher |
| Brandon Young | Mike Fletcher |
| Lee E. Cox | Off. Aaron Castor |
| Dennis Hill | Det. Christeson |
| Juhahn Jones | Drug Dealer |
| Brian E. McLarney | Off. Brian McLarney |
| Jermaine Shorts | Man |
| Jay Spadaro | Officer |
| Michael Ahl | Detective |
| Mike D. Anderson | Ghost |
| Chris Ashworth | Sergei 'Serge' Malatov |
| Zach Book | The Sun Graphics Designer |
| Anthony Bosco | The Sun Copy Editor |
| Keenon Brice | Aaron 'Bug' Manigault |
| Darrell Britt-Gibson | Darius 'O-Dog' Hill |
| Chris Clanton | Savino Bratton |
| Chris Conlon | Police Officer |
| Thuliso Dingwall | Kenard |
| Dave Ehrman | Researcher |
| Al Ghanekar | Photo Editor |
| Ethan Goldsmith | Von |
| Art Hall | Reporter |
| Aubrohn King | Detective |
| Marcus LaRon | Police Officer |
| Ken McNaughton | Bar Patron |
| Elizabeth Mary Nolan | Reporter |
| Karl Otter | District Commander |
| Carlyn Paschall | Court House Staff |
| Chad Ridgely | Justin Cook |
| Jennifer Rouse | Whiting's Secretary |
| Kevyn Settle | Sun Paper Layout Editor |
| Kevin L Simmons | Detective |
| Patrick Michael Strange | Reporter |