| Dominic West | Det. James 'Jimmy' McNulty |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Idris Elba | Russell 'Stringer' Bell |
| Frankie Faison | Acting Commissioner Ervin H. Burrell |
| Aidan Gillen | Councilman Thomas 'Tommy' Carcetti |
| Wood Harris | Avon Barksdale |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Lt. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Jim True-Frost | Det. Roland 'Prez' Pryzbylewski |
| Robert Wisdom | Maj. Howard 'Bunny' Colvin |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Det. Thomas 'Herc' Hauk |
| J.D. Williams | Preston 'Bodie' Broadus |
| Michael Kenneth Williams | Omar Little |
| Corey Parker Robinson | Det. Leander Sydnor |
| Isiah Whitlock Jr. | State Sen. R. Clayton 'Clay' Davis |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Jamie Hector | Marlo Stanfield |
| Brandy Burre | Theresa D'Agostino |
| Michael Hyatt | Brianna Barksdale |
| Melvin Williams | Deacon |
| Megan Anderson | Jen Carcetti |
| Clarence Clemons | Roman |
| Doug Olear | FBI Spec. Agent Terrance 'Fitz' Fitzhugh |
| Gbenga Akinnagbe | Chris Partlow |
| Benjamin Busch | Off. Anthony Colicchio |
| Ryan Sands | Off. Lloyd 'Truck' Garrick |
| Michael Willis | Andy Krawczyk |
| Richard Burton | Sean 'Shamrock' McGinty |
| Anwan Glover | Slim Charles |
| Jonathan Orcutt | Sheriff Robert Spore |
| William Zielinski | Gene |
| Mayo Best | Gerard |
| Kelli R. Brown | Kimmy |
| Christopher Mann | Councilman Anthony 'Tony' Gray |
| Brandan T. Tate | Sapper |
| Ernest Waddell | Dante |
| Perry Blackmon | Perry |
| Fran Boyd | Needle Exchange Worker |
| Tiara Harris | Devonne |
| Genevieve Hudson-Price | Dee Dee |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Ian Bonds | Drug Buyer in Car |
| R. Emery Bright | Community Relations Sgt. |
| MaConnia Chesser | Trina |
| Lee E. Cox | Off. Aaron Castor |
| Daryl D. Davis | Store Clerk |
| Anthony Fedd | Tucky |
| Lawrence Gilliard Jr. | D'Angelo Barksdale |
| Edward Bernard Green Jr. | Spider |
| Tamara Johnson | Lieut. Cindy Lowry |
| Nehal Joshi | Baba Jani |
| Karl Otter | District Commander |
| Jay Sefton | Political Analyst |
| Rico Whelchel | Rico |
| Delaney Williams | Sgt. Jay Landsman |
| Gregory L. Williams | Det. Michael Crutchfield |