| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Armin Mueller-Stahl | Israeli Prime Minister Efraim 'Eli' Zahavy |
| Makram Khoury | Palestinian Chairman Nizar Farad |
| Lily Tomlin | Deborah Fiderer |
| Steven Culp | Speaker of the House Jeff Haffley |
| Sam Robards | Greg Brock |
| H. Richard Greene | Senator Robert Royce, R-PA |
| Allison Smith | Mallory O'Brien |
| NiCole Robinson | Margaret Hooper |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Dey Young | Congresswoman |
| Jim Abele | Congressman Benoit |
| Blue Deckert | Congressman Borden |
| Richard V. Licata | Congressman Lackey |
| Jamie McShane | Dr. Hardin |
| Mindy Seeger | Chris |
| Ben Siegler | Reporter George |
| Don Snell | Congressman Briggs |
| Jeffry E. Stein | Steward |
| Izzy Diaz | Staffer |
| Marcie Lynn Ross | Treasury Secretary Karen Browning |
| Deirdre M. Smith | Nurse #1 |
| Pamela Bel Anu | Nurse #2 |
| Elizabeth Tulloch | Intern Susan |
| John Colella | Announcer |
| Alexander Hall | Secret Service Agent |