| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Laura Dern | U.S. Poet Laureate Tabatha Fortis |
| Emily Procter | Ainsley Hayes |
| NiCole Robinson | Margaret Hooper |
| Renée Estevez | Nancy |
| Yolanda Lloyd Delgado | 'Sunrise in Cincinnati' Anchor Terri |
| Beth Littleford | WKZN Philadelphia Anchor Leslie |
| James Eckhouse | Rep. Bud Wachtell, D |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Devika Parikh | Bonnie |
| Kim Webster | Ginger |
| Mindy Seeger | Chris |
| Kris Murphy | Katie Witt |
| Randy Brooks | Arthur Leeds
(as Randolph Brooks) |
| Timothy Davis-Reed | Mark O'Donnell |
| Jeff Mooring | Reporter Phil |
| Jana Lee Hamblin | Reporter Bobbi |
| Diana Morgan | Reporter Jesse |
| David Gautreaux | Reporter |
| Christopher Michael | Floor Manager |
| Tim Haldeman | Barnett |
| Jennifer Marley | College Student |
| Dan Beck | White House Cameraman
(uncredited) |
| Sean Allen Jones | Uniformed Secret Service Agent
(uncredited) |