| Rob Lowe | Sam Seaborn |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Elisabeth Moss | Zoey Bartlet |
| Claire Yarlett | Dr. Jenna Jacobs |
| Rebecca Creskoff | Sarah Jordan |
| James Denton | Tom Jordan
(as Jamie Denton) |
| NiCole Robinson | Margaret Hooper |
| Alfonso Freeman | Andrew Mackintosh |
| Myles Kilpatrick | Jeffrey Mackintosh
(as Myles Killpatrick) |
| Franc Ross | Sonny Saunders |
| Jesse Corti | Dave Stewart |
| Melissa Fitzgerald | Carol |
| Devika Parikh | Bonnie |
| Kim Webster | Ginger |
| Peter James Smith | Ed |
| William Duffy | Larry |
| Alan McRae | Gary with a 'G' |
| Heather Sullivan | White House Intern
(uncredited) |