| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer
(credit only) |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| CCH Pounder | Claudette Wyms |
| Forest Whitaker | Jon Kavanaugh |
| Ally Walker | Tori Burke |
| David Marciano | Steve Billings |
| Paula Garcés | Tina Hanlon
(as Paula Garces) |
| Onahoua Rodriguez | Emolia Melendez |
| Ammar Daraiseh | Gilbos Arkelian |
| Jordi Caballero | Aldo Melchor |
| Laura Harring | Rebecca Doyle |
| Melanie Myers | Paula |
| Yul L. Spencer | Tyrez 'Spank' Wallace
(as Yul Spencer) |
| Lance Irwin | Agent Gallagher |
| David Batiste | Kyle Irwin |
| James Molina | Julio |
| Autumn Chiklis | Cassidy Mackey
(credit only) |
| Bon Ogle | George |
| Leeah Jackson | Haley
(as Leeah D. Jackson) |
| Kwesi Boakye | Wendell |
| Matthew Pollino | Tejado |
| Ruben Avitia | Background Detective
(uncredited) |
| Mike Cochrane | Perp in Cage
(uncredited) |
| Jesse Escochea | Jesse
(uncredited) |