| Michael Chiklis | Vic Mackey |
| Glenn Close | Monica Rawling |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe
(credit only) |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| Michael Peña | Armando Renta |
| Laurence Mason | Halpern White |
| David Marciano | Steve Billings |
| Nigel Gibbs | Assistant Chief Roy Phillips |
| Onahoua Rodriguez | Emolia Melendez |
| Lennie Loftin | Tom |
| Petey Pablo | Weed |
| Jimmy Jean-Louis | Ididsa Okoye |
| Vincent Foster | Smitty
(as V.J. Foster) |
| Peter Vasquez | Gusano
(as Pete Vasquez) |
| Janelle Marra | Eliza
(as Janelle Giumarra) |
| Katarina Choi | Tracy |
| Jay Phillips | Jamani |
| Stacy Hall | Uni #1 |
| Dan Warner | Uni #2 |
| Virtic Brown | Woman
(as Virtic Emil Brown) |
| Dale E. Turner | Man |
| Ambrit Millhouse | Crying Woman |
| Sophia C. James | Sanura
(as Sophia Egharevba) |
| Ruben Avitia | Background Detective
(uncredited) |