| Michael Chiklis | Vic Mackey |
| Glenn Close | Monica Rawling |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky
(as Kenneth Johnson) |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| Michael Peña | Armando Renta |
| Anna Maria Horsford | A.D.A. Beth Encardi |
| Laurence Mason | Halpern White |
| Alex Fernandez | Bob Mamyn |
| David Marciano | Steve Billings |
| Donna Cooper | Olive /
Olivia Kenshaw |
| Dominic Hoffman | Louis Sperling |
| Joe Renteria | Cal |
| Anthony Anderson | Antwon Mitchell |
| Linda Friedman | Nina |
| Autumn Chiklis | Cassidy Mackey |
| Jack Weber | Matthew Mackey |
| Robert Wu | Scooby |
| Kelvin Brown | Fat Benish |
| Elijah Kelley | Jaymon |
| Marcus Lyle Brown | Cromo
(as Marcus Brown) |
| Marisa Lauren | Cromo's Girl |
| Chaney Kley | Officer Asher |
| Peter Pasco | Cyril |
| Jane Lanier | Medical Examiner |
| Kevin Nichols | McReeder |
| Bert Rosario | Plumber |
| Gregory White | Fire Captain |
| Noah Sife | Local |
| Josh Phillips | John |
| Benjamin A. Onyango | Store Clerk
(as Ben Onyango) |
| Erin Underwood | Hope |
| Roxanne Dover | Yo |
| Aasha Davis | Lucy |
| David Hawthorne | Zerkow |
| Ruben Avitia | Background Detective
(uncredited) |
| Orion McCabe | Irish Bagpipe performer
(uncredited) |
| Katey Sagal | Nancy Gilroy
(uncredited) |