| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| John Diehl | Assistant Chief Ben Gilroy |
| Tyra Ferrell | Karen Mitchell |
| Carlos Mencia | Gabo |
| Marquita Terry | Melissa Kramer |
| Robert LaSardo | Jojo Rizal |
| John Scherer | Gary Parsons |
| Dick Anthony Williams | Reverend Neal Cook |
| Cathy Cahlin Ryan | Corrine Mackey |
| Matt Corboy | Ray Carlson |
| Luis Saguar | Pazi Arambula |
| Courtney McLean | Dookie |
| Marcia Jeffries | Monique |
| Geoff Meed | Wally Forton |
| Lavelle Roby | Emily Berry |
| Autumn Chiklis | Cassidy Mackey |
| Alysia Joy Powell | Maya Duffy
(as Alysia Powell) |
| Rigo Sanchez | Pablo |
| Letty Lopez | Jesus' Girlfriend |
| Brian Britt | Young Angry Male #1 |
| Vincent Harris | Young Angry Male #2 |
| Francis Capra | Jesus Rosales
(uncredited) |
| Jon Huertas | Robbie Villanueva
(uncredited) |
| Omar McClinton | Officer Roman
(uncredited) |
| 'Big' LeRoy Mobley | Rioter
(uncredited) |
| John Strand | Riot Police #1
(uncredited) |