| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| Sticky Fingaz | Kern Little |
| John Diehl | Assistant Chief Ben Gilroy |
| Walter Jones | Rondell Robinson
(as Walter Emanuel Jones) |
| Mark Kiely | Pete Shockley |
| Dex Elliott Sanders | T-Bonz |
| Marc McClure | Jamison |
| Efrain Figueroa | Jorge Machado |
| Cathy Cahlin Ryan | Corrine Mackey |
| Camillia Monet | Aurora Aceveda
(as Camillia Sanes) |
| Chene Lawson | Tyesha |
| Linda Medina | Ellie Ruiz |
| Marlene Warfield | Dottie Cummings |
| Roy Jones | Henry |
| Christopher Perez | Eduardo Salcido |
| Joel Rosenthal | Matthew Mackey |
| Maurice Blake | Aaron |
| Ralph Rangel | Sanchez |
| German Leonne | Erubiel |
| Brian Britt | Freddie |
| Godofredo Henriquez | Drunken Migrant Worker |
| Cecilia Johnson | Shake Girl |
| Jessica Booker | Shake Girl |
| Natalia Swader | Shake Girl |
| Scooter Yancey | Off-Duty Officer
(as Henry Yancey) |