| Clive Owen | Dr. John W. Thackery |
| André Holland | Dr. Algernon Edwards |
| Jeremy Bobb | Herman Barrow |
| Juliet Rylance | Cornelia Robertson |
| Eve Hewson | Nurse Lucy Elkins |
| Michael Angarano | Dr. Bertie Chickering Jr. |
| Chris Sullivan | Tom Cleary |
| Cara Seymour | Sister Harriet |
| Eric Johnson | Dr. Everett Gallinger |
| David Fierro | Inspector Jacob Speight |
| Grainger Hines | Captain August Robertson |
| Charles Aitken | Henry Robertson |
| Tom Lipinski | Phillip Showalter |
| Colman Domingo | Dr. Russell Daniels |
| Ben Livingston | Dr. William H. Mays |
| Jefferson Mays | Attorney Whitting |
| Lucas Papaelias | Eldon Pouncey |
| Molly Price | Effie Barrow |
| Alexandra Roxo | Cate |
| Suzanne Savoy | Victoria Robertson |
| Gary Simpson | Hobart Showalter |
| Stephen Spinella | A.D. Elkins |
| Frank Wood | Mr. Havershorn |
| Perry Yung | Ping Wu |
| Happy Anderson | Jimmy |
| Michael Berresse | Parke-Davis Representative |
| Johanna Day | Eunice Showalter |
| Christopher Dalbey | Bleier Driver |
| David Destefano | Wrestler |
| Ylfa Edelstein | Nurse Baker |
| John Treacy Egan | Detective Satterlee |
| Ying Ying Li | Lin-Lin |
| John O'Creagh | Tammany Hall Official |
| Richard James Porter | Monsignor Joseph Mills Lawlor |
| Briana Pozner | Gwynnie Showalter |
| Lucas Caleb Rooney | Mr. Karwoski |
| Zuzanna Szadkowski | Nurse Pell |
| Ginger A. Taylor | Sonya Smyslov
(as Ginger Taylor) |
| Yury Tsykun | Mr. Tibor |
| Mitch Vallen | Otto
(as Mitchell Vallen) |
| Shane Copland | Wrestling Timekeeper
(uncredited) |
| Kathleen Culler | Dispensary Nurse
(uncredited) |
| Jesse Jantzen | Referee
(uncredited) |
| Sven Jähnert | Construction Worker
(uncredited) |
| Cameron McIntosh | Bartender
(uncredited) |
| And Palladino | Gallery Doctor
(uncredited) |
| Kerri Rose | Burlesque Dancer
(uncredited) |