| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston
(credit only) |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Danny Trejo | Romero 'Romeo' Parada |
| Ray McKinnon | Lincoln 'Linc' Potter |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Emilio Rivera | Marcus Alvarez |
| Tory Kittles | Laroy Wayne |
| Benito Martinez | Luis Torres |
| Jesse Garcia | Rafi |
| McNally Sagal | Margaret Murphy |
| Chris Reed | Philip 'Filthy Phil' Russell
(as Christopher Douglas Reed) |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Olivia Burnette | Homeless Woman |
| Al Vicente | The Collector |
| Matt Riedy | CHP Officer |
| Matt Orduna | Dr. Balian
(as Matt Orduña) |
| E.R. Ruiz | Gill
(as E.R) |
| Terrence Edwards | EMS |
| Christopher Michael | Watch Commander |
| Steve Wilcox | Masked Man #1 |
| Mustafa Speaks | Niner
(as Coley Mustafa Speaks) |
| Ella Allan | Baby Thomas Teller
(uncredited) |
| Mia Allan | Baby Thomas Teller
(uncredited) |