| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Chief Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ally Walker | Agent June Stahl |
| Paula Malcomson | Maureen Ashby |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Andy McPhee | Keith 'McGee' McGee
(as Andrew McPhee) |
| Jose Pablo Cantillo | Hector Salazar |
| Zoe Boyle | Trinity Ashby |
| Michael Beach | Taddarius Orwell 'T.O.' Cross |
| David Marciano | Chicken Man |
| Michael Fairman | Lumpy Feldstein |
| McNally Sagal | Margaret Murphy |
| Kevin P. Kearns | Luke Moran
(as Kevin Kearns) |
| Pamela Gray | Agent Amy Tyler
(as Pamela J. Gray) |
| Marcello Thedford | Lander Jackson |
| Chad Guerrero | Pozo |
| Stacy Hall | Sheriff |
| Ray Chavez Jr. | Warehouse Clerk |
| Wendy Haines | Nurse |
| Jimmy Sharp | Irish Thug |