| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| Johnny Lewis | Kip 'Half Sack' Epps |
| William Lucking | Piermont 'Piney' Winston
(credit only) |
| Theo Rossi | Juan Carlos 'Juice' Ortiz
(credit only) |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Adam Arkin | Ethan Zobelle |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Dayton Callie | Chief Wayne Unser |
| Mitch Pileggi | Ernest Darby |
| Henry Rollins | AJ Weston |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Michael O'Neill | Anthony Franklin |
| Winter Ave Zoli | Lyla Dvorak |
| Kenneth Choi | Henry Lin |
| Jason Matthew Smith | Ule |
| Olivia Burnette | Homeless Woman |
| Kristen Renton | Ima Tite |
| Chris Coy | Alex Franklin |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Marya Delver | Officer Eglee |
| Dennis Keiffer | Izzy |
| Sheila Shaw | Nurse |
| Aaron Jennings Hartnell | Trucker John
(uncredited) |
| Corinne Irizarry | Brown Sugar
(uncredited) |
| Selena Johnson | Choir Member
(uncredited) |
| Eric Shackelford | Drug Buyer
(uncredited) |
| Kurt Sutter | Otto
(uncredited) |