| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| Johnny Lewis | Kip 'Half Sack' Epps |
| William Lucking | Piermont 'Piney' Winston
(credit only) |
| Theo Rossi | Juan Carlos 'Juice' Ortiz
(credit only) |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Adam Arkin | Ethan Zobelle |
| Tom Arnold | Georgie Caruso |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Emilio Rivera | Marcus Alvarez |
| Dendrie Taylor | Luann Delaney |
| Patrick St. Esprit | Elliott Oswald |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Callard Harris | Edmond Hayes |
| Sarah Jones | Polly Zobelle |
| Winter Ave Zoli | Lyla Dvorak |
| Henry Rollins | AJ Weston |
| Kenneth Choi | Henry Lin |
| McNally Sagal | Margaret Murphy |
| Cleo King | Neeta |
| Bellina Logan | Fiona Larkin |
| Jason Matthew Smith | Ule |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Marya Delver | Officer Eglee |
| Jaye Razor | Muscle #1 |
| Phoenix Gonzales | Bartender
(as Phoenix Gonzalez) |
| Jim Veneziano | Jim |
| Adémola | Orderly
(uncredited) |
| Thomas Rosales Jr. | Mayan
(uncredited) |