| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford
(credit only) |
| Ryan Hurst | Harry 'Opie' Winston |
| Johnny Lewis | Kip 'Half Sack' Epps
(credit only) |
| William Lucking | Piermont 'Piney' Winston
(credit only) |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Tom Everett Scott | Rosen |
| Ally Walker | Agent June Stahl |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Glenn Plummer | Sheriff Vic Trammel |
| Patrick St. Esprit | Elliott Oswald |
| Julie Ariola | Mary Winston |
| Winter Ave Zoli | Lyla Dvorak |
| Liana Liberato | Tristen Oswald |
| Michael Bentt | Dion
(as Michael A. Bentt) |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Ronald William Lawrence | Russell Divine |
| Poncho Hodges | Smoke |
| Evan Lai | Angus |
| Jazzmun | Venus Bell |
| Shaun Russell | Prison Guard #1
(as T. Shaun Russell) |