| Peter Krause | Nate Fisher |
| Michael C. Hall | David Fisher |
| Frances Conroy | Ruth Fisher |
| Lauren Ambrose | Claire Fisher |
| Freddy Rodríguez | Federico 'Rico' Diaz |
| Mathew St. Patrick | Keith Charles |
| Jeremy Sisto | Billy Chenowith |
| Rachel Griffiths | Brenda Chenowith |
| Joanna Cassidy | Margaret Chenowith |
| Robert Foxworth | Dr. Bernard Chenowith |
| Illeana Douglas | Angela |
| Ed O'Ross | Nikolai |
| Eric Balfour | Gabe Dimas |
| Dina Spybey-Waters | Tracy Montrose Blair
(as Dina Waters) |
| Jed Allan | Dr. Gareth Feinberg |
| John Billingsley | Boring Man |
| Timm Sharp | Andy |
| Wendy Schaal | Vickie Dimas |
| Lisa K. Wyatt | Pam, Kroehner Mortician |
| Irina Maleeva | Irina |
| Lena Zhanik | Lotte
(as Lena Woroboff) |
| Tate Taylor | Job Applicant #1 |
| Scott Alan Smith | Job Applicant #2 |
| Bob Richardson | Homeless Man
(as Robert Richardson) |
| Jim Brooks | Devon
(uncredited) |
| Lynn Wanlass | Sally Hanley
(uncredited) |