| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Isidora Goreshter | Svetlana Fisher |
| Richard Flood | Ford |
| Elliot Fletcher | Trevor |
| Samantha Hanratty | Kassidi
(as Sammi Hanratty) |
| Cleo King | Registrar |
| Anil Kumar | Rami |
| Ruby Modine | Sierra |
| Jessica Szohr | Nessa |
| Jim Hoffmaster | Kermit |
| Michael Patrick McGill | Tommy |
| Chet Hanks | Charlie |
| Tina Ivlev | Freelania Alexeyevich |
| Ray Laska | Reverend Yates |
| Levy Tran | Eddie |
| Billy 'Sly' Williams | Linc |
| Nadja Alaya | Nina |
| Jeremy A. Lopez | Indio
(as Jeremy Andorfer-Lopez) |
| Nicco Annan | Deacon Cook |
| David Brackett | Duran |
| Nick Carson | Les |
| Brie Carter | Natasha |
| Bradley Dodds | Parsons |
| Eden Elyse | Tara |
| Scarlett Fernandez | Jeni |
| Michael DeMarco | Abe
(as Michael D. Finley) |
| Michael Gambino | Rodney |
| Brett Gipson | Michaels |
| Christian Isaiah | Liam Gallagher |
| John O'Brien | Father Monroe |
| Stacey Oristano | Trina |
| Eric Satterberg | Hassan |
| Kevin Sifuentes | Nunez |
| Taira Soo | Mei Ling |
| Scarlet Spencer | Xan |
| Kevyn Bashore | Patsy's Folk Patron
(uncredited) |
| Janelle Beck | Parking Lot Mom
(uncredited) |
| Alyssa Haglund | Ian's follower
(uncredited) |
| Shannon Mitrovich | Ian's Follower
(uncredited) |