| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Amaury Nolasco | Fernando Sucre |
| Wade Williams | Brad Bellick |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| Peter Stormare | John Abruzzi |
| Frank Grillo | Nick Savrinn |
| Lane Garrison | David 'Tweener' Apolskis |
| John Heard | Governor Frank Tancredi |
| Joe Nunez | Manche Sanchez |
| Daniel J. Travanti | President Richard Mills |
| Patricia Wettig | Vice President Caroline Reynolds |
| Stacy Keach | Warden Henry Pope |
| Phillip Edward Van Lear | Louis Patterson |
| Jennifer Joan Taylor | Becky |
| Anthony Fleming | Trumpets |
| DuShon Monique Brown | Nurse Katie Welch |
| Christian Stolte | Corrections Officer Keith Stolte |
| Mac Brandt | Corrections Officer Mack Andrews Andrews |
| Mark Morettini | C.O. Rizzo Green |
| Rich Komenich | Maggio |
| Nancy Loo | Nancy Loo - Reporter |
| Gary Houston | Suit #2 |
| Lea Coco | C.O. Coco |
| Javon Johnson | C.O. JJ |
| Ray Frewen | Suit #1 |
| James McCammond | Cell Mate |
| Mark Reisman | Makkos |
| James Krag | Suit #3 |
| Linda Gillum | Aide |
| Randall Jones | Secret Service Agent |
| Zachary Laoutides | Prisoner |
| Joseph L. Rubino | Psychiatric Patient |
| John Stacho | Governors Aid |
| David Dino Wells Jr. | Trumpets Right-hand Man |