| Pedro Pascal | Javier Peña |
| Damián Alcázar | Gilberto Rodríguez Orejuela |
| Alberto Ammann | Pacho Herrera |
| Francisco Denis | Miguel Rodríguez Orejuela |
| Pêpê Rapazote | Chepe Santacruz Londoño |
| Matias Varela | Jorge Salcedo |
| Andrea Londo | Maria Salazar |
| Michael Stahl-David | Chris Feistl |
| Matt Whelan | Daniel Van Ness |
| Eric Lange | Bill Stechner |
| Arturo Castro | David Rodriguez |
| José María Yazpik | Amado Carrillo Fuentes
(as José María Yázpik) |
| Brett Cullen | Arthur Crosby |
| Andrés Crespo | Carlo Córdova |
| Juan Sebastián Calero | Navegante
(as Juan Sebastian Calero) |
| Arnold Cantillo | Flaco |
| Carrell Lasso | Enrique |
| Juan Carlos Messier | Gustavo Calderon
(as Juan Messier) |
| Juan Pablo Shuk | Colonel Martinez |
| Taliana Vargas | Paola Salcedo |
| Raymond Ablack | Stoddard |
| Margarita Rosa de Francisco | Carolina Álvarez |
| Sebastian Eslava | Nicolas Rodriguez |
| Jorge Monterrosa | Trujillo
(as Jorge Monterroza) |
| Gabriel Sloyer | Manuel de Dios Unane |
| Roberto Cano | Darío |
| Vicky Hernández | Gerda Salazar |
| Jerónimo Barón | Pedro Salazar |
| Carlos Rios | Duvan Salazar |
| Jaime Arango | Raul Salazar |
| Marcela Gallego | Mariela Rodriguez |
| Natalia Jerez | Aura |
| Juliette Pardau | Camila |
| Tristán Ulloa | Ernesto Samper |
| Luis Mesa | Fernando Botero |
| Matias Maldonado | Attorney General Valdivieso |
| Santiago Dorronsoro | Senator |
| Carlos Peláez | Sub-Lieutenant |
| Andres Salazar | Presidential Page
(as Andrés Salazar) |
| Cristian Sarmiento | Fercho |
| Laura Londoño | Katie |
| Álvaro García | General Diego Vargas |
| Joao Oliveros | CNP Officer |
| Alberto Suárez | CNP Officer 2 |
| Wendy Susan Hammer | Waitress |
| Daniel Guerrero | Security Guard |
| Jose Lizarde Jr. | Cartel Leader
(uncredited) |