| Diego Luna | Miguel Ángel Félix Gallardo |
| Scoot McNairy | Walt Breslin |
| José María Yazpik | Amado Carrillo Fuentes |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Gerardo Taracena | Pablo Acosta |
| Alfonso Dosal | Benjamín Arellano Félix |
| Mayra Hermosillo | Enedina Arellano Felix |
| Manuel Masalva | Ramón Arellano Félix |
| Teresa Ruiz | Isabella Bautista |
| Miguel Rodarte | Danilo Garza |
| Alex Knight | Kenny |
| Jesse Garcia | Sal Orozco |
| Matt Biedel | Daryl Petsky |
| Jero Medina | Ossie Mejía |
| Alberto Zeni | Amat Palacios |
| Andres Londono | Enrique Clavel |
| Flavio Medina | Juan García Abrego |
| Michael Peña | Enrique 'Kiki' Camarena |
| Pedro Giunti | Sergio Verdín |
| Jesús Ochoa | Juan Nepomuceno Guerra |
| Sosie Bacon | Mimi Webb Miller |
| Quavo | Quavo |
| Andrés Almeida | Cochiloco |
| Francisco Barreiro | Francisco Arellano Félix |
| José Julián | Javier Arellano Félix |
| Sebastián Buitrón | Eduardo Arellano Félix |
| Bobby Soto | David Barron |
| Noé Hernández | Rafael Aguilar |
| Mauricio Núñez Nava | Néstor |
| Alfonso Borbolla | Marco de Haro |
| Luna Beltran | Isabel Arellano Félix |
| Marilyn Uribe | Alicia María Arellano Félix |
| Roxana Saucedo | Esperanza |
| Víctor César Villalobos | Óscar |
| Érick Israel Consuelo | Manny |
| Rubén Jiménez | Captain |
| Danny Balderas | Busboy |
| Gotzon Zuloaga | Man |
| Roberto Tello | AFO Driver |