| Michael Peña | Enrique 'Kiki' Camarena |
| Diego Luna | Miguel Ángel Félix Gallardo |
| Joaquín Cosio | Ernesto 'Don Neto' Fonseca Carrillo |
| Alyssa Diaz | Mika Camarena |
| José María Yazpik | Amado Carrillo Fuentes |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Matt Letscher | James Kuykendall |
| Julio Cesar Cedillo | Guillermo González Calderoni |
| Teresa Ruiz | Isabella Bautista |
| Gerardo Taracena | Pablo Acosta |
| Lenny Jacobson | Roger Knapp |
| Aaron Staton | Butch Sears |
| Scoot McNairy | Walt Breslin |
| Fermín Martínez | El Azul |
| Horacio Garcia Rojas | Tomás Morlet |
| Guillermo Villegas | Sammy Álvarez |
| Alfonso Dosal | Benjamín Arellano Félix |
| Manuel Masalva | Ramón Arellano Félix |
| Clark Freeman | Ed Heath |
| Yul Vazquez | John Gavin |
| Christopher Stanley | Jack Lawn |
| Rodrigo Murray | Governor Leopoldo Celis |
| Alberto Casablanca | Rodolfo Celis |
| Alberto R. Ruiz | Luis |
| Alejandro Bracho | Mr. X |
| Mark Kubr | Tony |
| Gorka Lasaosa | Héctor Palma |
| Edison Ruíz | Comandante Méndez |
| Pedro Giunti | Sergio Verdín |
| Emilio Guerrero | Humberto Machaín |
| Joshua Okamoto | Manuel |
| Francisco Barreiro | Francisco Arellano Félix |
| Gary Poux | Pathologist |
| Israel Islas | Comandante Pavón |
| Alex Knight | Kenny |
| Alessandro Borrelli | Kiki Jr. |
| Daniel Damuzi | Braulio |
| Manuel Sevilla | Well Dressed Man |
| Paola Flores | Celis Maid |
| Christopher Friessen | Mexican Border Agent |
| Alejandro Briones | MFKP Cop #2 |
| Roberto Mares | MFKP Cop #3 |
| Cristian Gerardo Martínez | Palma Bodyguard |
| Uriel Mendoza | Cop #1 |
| Giovani Florido | Young Cop |
| Ricardo Mansur | Concierge |
| Martín Casanova | Bar Owner |
| Fabián Pazzo | Tapia |