| Charlie Cox | Matt Murdock |
| Deborah Ann Woll | Karen Page |
| Elden Henson | Foggy Nelson |
| Toby Leonard Moore | James Wesley |
| Bob Gunton | Leland Owlsley |
| Vincent D'Onofrio | Wilson Fisk
(voice) |
| Peter McRobbie | Father Lantom |
| Daryl Edwards | Detective Hoffman |
| Chris Tardio | Detective Blake |
| John Patrick Hayden | Jack Murdock |
| Skylar Gaertner | Young Matt Murdock |
| Nikolai Nikolaeff | Vladimir |
| Gideon Emery | Anatoly |
| Peter Shinkoda | Nobu |
| Wai Ching Ho | Madame Gao |
| Rob Morgan | Turk Barrett |
| Royce Johnson | Sgt. Brett Mahoney |
| J. Tucker Smith | Clyde Farnum |
| Tonya Glanz | Susan |
| Elise Kibler | Tracy Farnum |
| Erick Abbate | Boy |
| Richie Allan | Elderly Man |
| Raul Dedos | Officer #1 |
| Jessica Park | Brunette |
| Craig Henningsen | Mr. Rance
(uncredited) |
| Ilan Krigsfeld | Gun Dealer
(uncredited) |
| Dennis Lauricella | NYPD Officer
(uncredited) |
| Roberto Lopez | The Russian Driver
(uncredited) |
| Pedro Marcelino | Bomb Blast Victim
(uncredited) |