| Jon Hamm | Don Draper |
| Elisabeth Moss | Peggy Olson |
| Vincent Kartheiser | Pete Campbell |
| January Jones | Betty Draper |
| Christina Hendricks | Joan Holloway |
| Bryan Batt | Salvatore Romano
(credit only) |
| Michael Gladis | Paul Kinsey |
| Aaron Staton | Ken Cosgrove |
| Rich Sommer | Harry Crane |
| Maggie Siff | Rachel Menken
(credit only) |
| Robert Morse | Bertram Cooper |
| John Slattery | Roger Sterling |
| Anne Dudek | Francine Hanson |
| Kate Norby | Carol McCardy |
| Shayna Rose | Rosemary |
| Teddy Sears | Kicks Matherton |
| Darby Stanchfield | Helen Bishop |
| Andy Umberger | Dr. Arnold Wayne |
| Gary Ballard | Waiter |
| Alison Brie | Trudy Campbell
(voice) |
| La Monde Byrd | Hollis |
| Allison Fleming | Round Mom |
| Susan Grace | Delia |
| Doug Hale | Charlie |
| Maxwell Huckabee | Robert Draper |
| Julie McNiven | Hildy |
| Flora Plumb | Gaudy Hat |
| Kiernan Shipka | Sally Draper |
| Dawn Marie Anderson | Receptionist
(uncredited) |
| Candice Cunningham | Secretary
(uncredited) |
| Eve Curtis | Secretary
(uncredited) |
| Rosemarie DeWitt | Midge Daniels
(uncredited) |
| Jeff Doden | Kissing Couple
(uncredited) |
| Emelle | Secretary
(uncredited) |
| Monica Ford | Secretary
(uncredited) |
| Rosemary Garris | Secretary
(uncredited) |
| Shiloh Goodin | Woman at Bar
(uncredited) |
| Britt Hysen | Secretary
(uncredited) |
| Richard Kreps | Paramedic
(uncredited) |
| Rick Mattoon | Paramedic
(uncredited) |
| Morgan Rusler | Mack Johnson
(uncredited) |
| Jennifer Sims | Secretary
(uncredited) |
| Arne Starr | The Artist
(uncredited) |
| Erin Stutland | Susan
(uncredited) |