| Tom Ellis | Lucifer Morningstar |
| Lauren German | Chloe Decker |
| Kevin Alejandro | Dan Espinoza |
| Tricia Helfer | Charlotte |
| D.B. Woodside | Amenadiel
(as DB Woodside) (credit only) |
| Lesley-Ann Brandt | Mazikeen
(credit only) |
| Aimee Garcia | Ella Lopez |
| Scarlett Estevez | Trixie Espinoza |
| Tom Welling | Marcus Pierce
(credit only) |
| Rachael Harris | Linda Martin
(credit only) |
| Suzanne Cryer | Grace Foley |
| Ian Reed Kesler | The Fixer |
| Matthew Yang King | Adrian Yates |
| Omar Leyva | Lalo Vasquez |
| LaFonda Baker | Uni |
| Troy Blendell | Larry |
| Jeff Bowser | Simon Fisher |
| Justin Chu Cary | Benson Reeves |
| Chelsea Gilson | Blonde Model |
| Alexia Rae Castillo | Brunette Angel Model
(uncredited) |