| Louis C.K. | Louie |
| Hadley Delany | Lilly |
| Ursula Parker | Jane |
| Pamela Adlon | Pamela |
| Nate Fernald | Bart Folding
(as Nathan Fernald) |
| Jimmy Fallon | Jimmy Fallon |
| Mike Bocchetti | Mike |
| Steven Wright | Comic Strip MC |
| Jorge Chapa | Bodega Man |
| Lino Del Core | Italian Restaurant Waiter |
| Lauren Doucette | Parmesan Cheese Lady |
| Lauren Elder | Fan |
| Evan Fine | Young Louie |
| Rénayla Joye | Comic #2
(as Renayla Joye) |
| Mahira Kakkar | Check-Out Clerk |
| Dave Konig | Matchie
(as David Konig) |
| Eléonore Pourriat | French Actress
(as Eleonore Pourriat) |
| Angel Rosa | Policeman |
| Lily Peterson | Student |