| Jerry Orbach | Detective Lennie Briscoe |
| Benjamin Bratt | Detective Rey Curtis |
| S. Epatha Merkerson | Lieutenant Anita Van Buren |
| Sam Waterston | E.A.D.A. Jack McCoy |
| Angie Harmon | A.D.A. Abbie Carmichael |
| Steven Hill | D.A. Adam Schiff |
| Mark Blum | Defense Attorney Frank Lazar |
| Christina Haag | Kitty Lansing |
| Barbara Andres | Anne O'Brien |
| Alex Wipf | Mr. O'Brien |
| J.K. Simmons | Dr. Emil Skoda |
| Christopher Patrick Mullen | Matt Bergstrom |
| Leslie Hendrix | M.E. Dr. Elizabeth Rodgers |
| Larry Clarke | Detective Morris LaMotte |
| Clark Middleton | Ellis |
| Tracy Sallows | Erica Davies |
| Alexander Robert Scott | Michael Ashford |
| Elizabeth Connors | Michelle Ashford |
| Stevie Ray Dallimore | Roger Lansing |
| Jordan Bayne | Melody Kane |
| Alison Sheehy | Morgan Bryant |
| David Alan Basche | Jack McKinney |
| Lee Shepherd | Defense Attorney Barry Kaufer |
| Christopher Innvar | Gavin Lapeer |
| John Leonard Thompson | Sam Franklin |
| Jenifer Krater | Diane Bauer |
| Valerie Leonard | Eileen Wimberly |
| Issac Bright | Eddy Acosta |
| Sal Petraccione | Ray Cardenas |
| Jay Raphael | Jerry Warner |
| Saidah Arrika Ekulona | Dr. Claire Metoyer |
| Ayo Haynes | Natalie Antos |
| Nadine Mozon | Assistant M.E. Janet Glynn |
| Donna Villella | CSU Technician Donna Richter |
| Lin Tucci | Amy Cardenas |
| Lee D'Angelo | Helen Kurtzman |
| Steven Zirnkilton | Narrator |