| Anna Maxwell Martin | Beelzebub |
| Elizabeth Berrington | Dagon, Lord of the Files |
| Adria Arjona | Anathema Device |
| Ned Dennehy | Duke of Hell Hastur |
| Andy Hamilton | Hell's Usher |
| David Tennant | Crowley |
| Andre Nightingale | Gate Guard |
| Michael McKean | Shadwell |
| Miranda Richardson | Madame Tracy |
| Michael Sheen | Aziraphale |
| Sam Taylor Buck | Adam Young |
| Amma Ris | Pepper |
| Alfie Taylor | Wensleydale |
| Daniel Mays | Arthur Young |
| Bill Paterson | Tadfield Neighbourhood Watch |
| Frances McDormand | Narrator |
| Jack Whitehall | Newton Pulsifer |
| Mireille Enos | War |
| Yusuf Gatewood | Famine |
| Brian Cox | Death |
| Ilan Galkoff | Brian |
| Caitlin Thorburn | Roisin Reidy |
| Michel Diercks | J Braun |
| Clayton Adams | Bruce Corbally |
| Jamie Hill | Death Performer |
| Lourdes Faberes | Pollution |
| Gina Gangar | Dr. M. Banerjee |
| Jon Hamm | Gabriel |
| Benedict Cumberbatch | Satan |
| Sian Brooke | Deirdre Young |
| Niall Greig Fulton | Satan |
| Simon Merrells | International Express Man |
| Tim Wallers | British Agent |
| Georg Nikoloff | Russian Agent |
| Paul Chahidi | Sandalphon |
| Gloria Obianyo | Uriel |
| Doon Mackichan | Archangel Michael |
| Paul Adeyefa | Disposible Demon |
| Sanjeev Bhaskar | Giles Baddicombe |
| Bryony Corrigan | Virtue Device |
| Dan Antopolski | John Device |
| Danny Hayes | Lawyer Robey |
| Ollie | Dog |
| Milo | Dog, South Africa |
| Tina Chiang | Chinese Nuclear Scientist |
| Sean James | Lorry Driver |
| Meg Kubota | Hastur as Woman in Park |
| Riccardo Mazzi | Waiting Staff |
| Angela Yeoh | Chinese Technician |
| Nina Mangold | Passerby |
| Jag Patel | Driver |
| Vic Waghorn | Village Vicar |