| Anna Torv | Olivia Dunham |
| Joshua Jackson | Peter Bishop |
| Lance Reddick | Phillip Broyles |
| Kirk Acevedo | Charlie Francis |
| Blair Brown | Nina Sharp |
| Jasika Nicole | Astrid Farnsworth |
| John Noble | Dr. Walter Bishop |
| Jared Harris | David Robert Jones |
| Michael Gaston | Sanford Harris |
| Noah Bean | FBI Agent |
| Chance Kelly | Mitchell Loeb |
| Kenneth Tigar | Warden Johan Lennox |
| Philip LeStrange | Tommie |
| Chinasa Ogbuagu | ND Agent #1 |
| John Wu | Paramedic #1 |
| Clark Middleton | Edward Markham |
| Eric L. Abrams | Davis
(as Eric Lenox Abrams) |
| Adam Ludwig | German Prison Guard #1 |
| Henning Fischer | German Prison Guard #2 |
| Elizabeth A. Davis | Joanne
(as Elizabeth Davis) |
| Chad Gittens | ND FBI Tech |
| Darby Lynn Totten | ND Agent #2
(as Darby Totten) |
| Anthony C. Mazza | ND Swat #1
(as Anthony Mazza) |
| Robert Matzelle | ND Swat #2 |
| Ben Van Bergen | Bookstore Customer
(as Ben Van Vergen) |
| Michael Cerveris | The Observer
(uncredited) |
| Lee Cunningham | Doctor
(uncredited) |
| James Frain | Mr. Kohl
(uncredited) |
| Ed Kalegi | German Prison Guard
(uncredited) |