| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street
(credit only) |
| Aimee Teegarden | Julie Taylor |
| Austin Nichols | Noah Barnett |
| Jessalyn Gilsig | Shelley Hayes |
| Daniella Alonso | Carlotta Alonso |
| Brad Leland | Buddy Garrity |
| Ben Ciaramello | Santiago Herrera
(as Benny Ciaramello) |
| Jana Kramer | Noelle Davenport |
| Kim Smith | Lauren Davis |
| Brooke Langton | Jackie Miller |
| Dana Wheeler-Nicholson | Angela Collette |
| Derek Phillips | Billy Riggins |
| Liz Mikel | Corrina Williams |
| Stacey Oristano | Mindy Collette |
| Louanne Stephens | Grandma Saracen |
| Blue Deckert | Mac McGill |
| Libby Villari | Mayor Rodell |
| Whitney McCauley | Sheila Williams |
| Nieko Mann | Noannie Williams |
| Joey Oglesby | Guy Raston |
| C. Anthony Jackson | Marcus Gordon |
| Wil Pollard | Wil |
| Kendrick Jefferson | Kendrick |
| Travis Harper | Freshman |
| Brent McGregor | Indie Music Kid |
| Richard Nance | Car Seller |
| Daniel B. Howard | Newspaper Geek |
| Matt Joyner | Player #1 |
| Todd McMullen | Miami Pete |
| Bria Wall | Cheerleader Friend |
| Parker Danks | Pep Rally Fan
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| Matt Goudreau | Pep Rally Hype Man
(uncredited) |
| Regan Licciardello | Pep Rally Fan
(uncredited) |
| Amy Quick Parrish | Teacher
(uncredited) |
| Aundrus Poole | Reggie Seale
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Alicia Shaddeau | Panthers Cheerleader /
Dillon Student /
Dillon Débutante
(uncredited) |
| Gary Teague | Teacher
(uncredited) |