| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Walter Perez | Bobby 'Bull' Reyes |
| Brad Leland | Buddy Garrity |
| Blue Deckert | Mac McGill |
| Derek Phillips | Billy Riggins |
| Libby Villari | Mayor Lucy Rodell |
| Katherine Willis | Joanne Street |
| Mark Nutter | Mitchell Street |
| Louanne Stephens | Mrs. Saracen |
| Liz Mikel | Corrina Williams |
| Nieko Mann | Noannie Williams
(as Brittany 'Nieko' Mann) |
| Whitney McCauley | Sheila Williams |
| Sabra Fuller | Mary Ann Granger |
| Merrilee McCommas | Pam Garrity |
| Cindy Creekmore | Missy Aubrey |
| Chris Doubek | Young Doctor |
| Michael Costello | Doctor Kroll |
| Anne Clarke | Drew
(as Anne Clark) |
| Stephen Bishop | Interviewer |
| Sid Johnson | Reverend Grady
(as Pastor Sid Johnson) |
| Peter Heckmann | Reverend Locke |
| Ravin Alexander | Crying Cheerleader |
| Joseph Cheatham | Fat Guy |
| Steven Chester Prince | Reg
(as Steve Prince) |
| Gene Bolton | San Marcus Special Teams Coach
(uncredited) |
| Nick Brandt | Aaron Banks
(uncredited) |
| Kelley Estes | Rally Girl
(uncredited) |
| Cynthia Huerta | Nurse
(uncredited) |
| Lowell Moore | (uncredited) |
| Robin Prough | Cheerleader
(uncredited) |
| Renay Rossi | Fan
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Heath Young | Football fan
(uncredited) |