| Jonathan Rhys Meyers | King Henry VIII |
| Henry Cavill | Charles Brandon |
| Lothaire Bluteau | Ambassador Charles de Marillac |
| Sarah Bolger | Mary Tudor |
| Max Brown | Edward Seymour |
| David O'Hara | Henry Howard, Earl of Surrey |
| Joely Richardson | Catherine Parr |
| Anthony Brophy | Ambassador Bishop Chapuys |
| Simon Ward | Bishop Gardiner |
| Selma Brook | Brigitte |
| Emma Hamilton | Anne Stanhope |
| Frank McCusker | Risley |
| Andrew McNair | Thomas Seymour |
| Rod Hallett | Richard Rich |
| Suzy Lawlor | Anne Parr |
| Laoise Murray | Lady Elizabeth |
| Maude Hirst | Kat Ashley |
| Aiden Condron | English Officer |
| Fabio Tassone | Duke of Nájera |
| Dennis Quilligan | Dr. Butts |
| Moe Dunford | Richard Leland |
| Jody Latham | Harry Hurst |
| Eoin Murtagh | Prince Edward |
| Jane Brennan | Lady Bryan |
| Elliot Moriarty | Queen's secretary |
| Jack Sandle | Hugh Latimer |
| Daniel Caltagirone | Girolamo de Treviso |
| Eoin Macken | English Officer |
| Owen Aaronovitch | Monsieur Rousselot |
| David Michael Scott | Officer |
| Art Kearns | Mr. Man |
| Roseanne Lynch | Camp Woman |
| Ian Saynor | Surgeon General |
| Aisling Holian | Catherine Parr's Lady in Waiting |
| Natasha Quirke | Catherine Parr's Lady in Waiting |
| Heitor Cavalheiro | Spanish Court Member |