| Jonathan Rhys Meyers | King Henry VIII |
| Henry Cavill | Charles Brandon |
| Lothaire Bluteau | Ambassador Charles de Marillac |
| Sarah Bolger | Mary Tudor |
| Max Brown | Edward Seymour |
| David O'Hara | Henry Howard, Earl of Surrey |
| Joely Richardson | Catherine Parr |
| Anthony Brophy | Ambassador Bishop Chapuys |
| Simon Ward | Bishop Gardiner |
| Emma Hamilton | Anne Stanhope |
| Frank McCusker | Risley |
| Andrew McNair | Thomas Seymour |
| Rod Hallett | Richard Rich |
| Tara Breathnach | Lady Mary's Lady-in-Waiting |
| Laoise Murray | Lady Elizabeth |
| Martyn Ellis | John Leigh |
| Stephen Russell | Lord Latimer's servant |
| Michael Elwyn | Lord Latimer |
| Alexander Downes | Surrey's Captain |
| Michael Wilson | Lord Glencairn |
| James Sutherland | Lord Maxwell |
| Eoin Murtagh | Prince Edward |
| Jane Brennan | Lady Bryan |
| Maude Hirst | Kat Ashley |
| Guy Carleton | Chamberlain |
| Sean Duggan | Ambassador Chapuy's servant |
| Ben Morris | Seymour's servant |
| Ciaran Kenny | Soldier |
| Lee Williams | Robert Testwood |
| Paul Connaughton | Edmund Harman |
| Fergal Titley | John Marbeck |
| Aisling Holian | Catherine Parr's Lady in Waiting |
| Selma Brook | Brigitte |
| Séamus Hanly | Scottish Soldier |
| Timuçin Leflef | Hudson Servant |