| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Aida Turturro | Janice Soprano Baccalieri |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Vincent Curatola | Johnny 'Sack' Sacramoni |
| Frank Vincent | Phil Leotardo |
| Ray Abruzzo | Carmine Lupertazzi Jr. |
| Sharon Angela | Rosalie Aprile |
| Dan Grimaldi | Patsy Parisi |
| Jerry Adler | Hesh Rabkin |
| Sydney Pollack | Warren Feldman |
| Peter Bogdanovich | Dr. Elliot Kupferberg |
| Daniel Baldwin | Sally Boy |
| Christopher McDonald | Eddie Dunne |
| Jonathan LaPaglia | Michael the Cleaver |
| Geraldo Rivera | Geraldo Rivera |
| Matt Servitto | Agent Dwight Harris |
| Cara Buono | Kelli Moltisanti |
| Dania Ramirez | Blanca Selgado |
| Tony Darrow | Larry Boy Barese |
| Arthur J. Nascarella | Carlo Gervasi
(as Arthur Nascarella) |
| Greg Antonacci | Butch DeConcini
(as Gregory Antonacci) |
| Maureen Van Zandt | Gabriella Dante |
| Lou Martini Jr. | Anthony Infante |
| John Bianco | Gerry Torciano |
| Denise Borino-Quinn | Ginny Sacrimoni |
| Caitlin Van Zandt | Allegra Sacrimoni |
| Cristin Milioti | Catherine Sacrimoni |
| Michael Kelly | Agent Ron Goddard |
| Maulik Pancholy | Dr. Ajit Gupte |
| Seth Barrish | Dr. Uri Rosen |
| John Wu | Morgan Yam |
| Matthew Weiner | Manny Safier |
| Jerry Capeci | Jerry Capeci |
| Martin Gobbee | Priest |
| Marianne Leone | Joanne Moltisanti |
| Geraldine LiBrandi | Patty Leotardo |
| John 'Cha Cha' Ciarcia | Albie Cianflone |
| Anthony J. Ribustello | Dante Greco |
| Daniel P. Conte | Faustino 'Doc' Santoro
(as Dan Conte) |
| Kevin McKelvey | U.S. Marshal Lunt
(as Kevin McKelvy) |
| Bruce Faulk | U.S. Marshal Rawley
(as Bruce Falk) |
| Maria Iadonisi | Larry Barese's Wife |
| Ariana DiLorenzo | Alexandra Lupertazzi |
| Allison Dunbar | Nicole Lupertazzi |
| Sam Semenza | Carmine Lupertazzi III |
| Derek Milman | Film Type |
| Angelo Massagli | Bobby Baccalieri Jr. |
| Miryam Coppersmith | Sophia Baccalieri |
| Avery Elaine Pulcher | Domenica Baccalieri |
| Emily Ruth Pulcher | Domenica Baccalieri |
| Kobi George | Hector Selgado |
| Kadin George | Hector Selgado |
| Jane Kim | Dominique |
| Joe Giordanella | Nicky
(as Lenny Ligotti) |
| George Pogatsia | Frankie |
| Susan Porro | J.T. Dolan's Girlfriend |
| Matt Pepper | Agent Ron Gosling |
| Lewis J. Stadlen | Dr. Ira Fried |
| Guy A. Fortt | Guard
(as Guy Fortt) |
| Ralph McCain | Another Patient |
| Anna Mancini | Donna Parisi |
| Chris Caldovino | Billy Leotardo
(as Christopher Caldovino) |
| Jo Newman | Gerry's Goomar |
| Julie Rogelstad | Silvio's Goomar |
| Bruce Bennetts | Photographer |
| Nicholas Mazzeo | Boy #1 |
| Jacob Lobosco | Boy #2 |
| Francesco Fusaro | Boy #3 |
| Justine Caputo | Girl #1 |
| Gia Bella Adamo | Girl #2 |
| Tim Daly | J.T. Dolan |
| Tommy Bayiokos | Scarface
(uncredited) |
| Dominic Chianese | Junior Soprano
(uncredited) |
| Joe Remy Dolinsky | Movie Guest
(uncredited) |
| Joey Giambattista | Shooter
(uncredited) |
| Jack Hammel | Wiseguy
(uncredited) |
| Tony Lip | Carmine Lupertazzi
(uncredited) |
| Ashley Monique Menard | Movie Patron
(uncredited) |
| Mark Sposato | Partygoer
(uncredited) |
| Sonny Vellozzi | Man in Restaurant
(uncredited) |