| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano
(as Jamie-Lynn DiScala) |
| Drea de Matteo | Adriana La Cerva |
| Aida Turturro | Janice Soprano
(credit only) |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Kathrine Narducci | Charmaine Bucco
(as Katherine Narducci) |
| Steve Buscemi | Tony Blundetto |
| Jerry Adler | Hesh Rabkin |
| Hill Harper | Stokley Davenport, M.D. |
| Frank Vincent | Phil Leotardo |
| Rae Allen | Aunt Quintina Blundetto |
| Carl Capotorto | Little Paulie Germani |
| Lola Glaudini | Agent Deborah Ciccerone-Waldrup |
| Karen Young | Agent Robyn Sanseverino |
| Joseph R. Gannascoli | Vito Spatafore |
| Dan Grimaldi | Patsy Parisi |
| Robert Funaro | Eugene Pontecorvo |
| Max Casella | Benny Fazio |
| Frank Pellegrino | Bureau Chief Frank Cubitoso |
| Frank Pando | Agent Frank Grasso |
| Will Janowitz | Finn DeTrolio |
| Joe Maruzzo | Joe Peeps |
| David Deblinger | Dr. Rene Katz |
| Joseph Costa | Fred Mosconi, M.D. |
| Michelle Christian Corp | Janet Petit, R.N.
(as Christian Corp) |
| Anthony J. Ribustello | Dante Greco |
| Duke Valenti | Corky DiGioia |
| William DeMeo | Jason Molinaro |
| Paolo Pagliacolo | Sicilian
(as Paul Paglia) |
| Maureen Van Zandt | Gabriella Dante |
| Tony Siragusa | Frankie Cortese |
| Mia Troche | Bing Girl |
| Jamie Sorrentini | Mimi |
| Andy Babiuk | The Chesterfield Kings |
| Mike Boise | The Chesterfield Kings |
| Paul Morabito | The Chesterfield Kings |
| Greg Prevost | The Chesterfield Kings |
| Krystal Browning | Upper-Class Restaurant Patron
(uncredited) |
| Michael Christaldi | Gangster in Bar
(uncredited) |
| Scott Addison Clay | Crazy Horse Patron
(uncredited) |
| Jennifer Rapp | Meadow's Friend
(uncredited) |