| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Vincent Pastore | Salvatore 'Big Pussy' Bonpensiero |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Nancy Marchand | Livia Soprano |
| Michael Gaston | Alex Mahaffey |
| Joe Lisi | Dick Barone |
| John Ventimiglia | Artie Bucco |
| Jerry Adler | Hesh Rabkin |
| Alton Clinton | MRI Technician |
| Phil Coccioletti | Nils Borglund |
| Michele DeCesare | Hunter Scangarelo
(as Michele de Cesare) |
| Drea de Matteo | Adriana La Cerva |
| Elaine del Valle | Sandrine |
| Giuseppe Delipiano | Restaurant Owner |
| Siberia M. Federico | Irina Peltsin
(as Siberia Federico) |
| Justine Miceli | Nursing Home Director |
| Kathrine Narducci | Charmaine Bucco
(as Katherine Narducci) |
| Joe Pucillo | Beppy Scerbo |
| Michael Santoro | Father Phil Intintola |
| Bruce Smolanoff | Emil Kolar |
| Vito Picone | Vito
(uncredited) |
| Craig Zucchero | Uncle Junior's Bodyguard
(uncredited) |