| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Capt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| Ray Stevenson | Isaak Sirko |
| Yvonne Strahovski | Hannah McKay |
| Aimee Garcia | Jamie Batista |
| Jason Gedrick | George Novikov |
| Katia Winter | Nadia |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Evan George Kruntchev | Harrison Morgan |
| Luke Andrew Kruntchev | Harrison Morgan |
| Andrew Kirsanov | Jurg Yeliashkevych |
| Francisco Viana | Det. Jake Simms |
| Dana L. Wilson | Det. Angie Miller |
| Rudy Quintanilla | Francisco |
| Bart Braverman | Marina Master |
| David Fraioli | Gunman |
| Santiago Cabrera | Sal Price
(voice) (uncredited) |
| Lee Christian | Kissing Gay Bar Patron
(uncredited) |
| Enver Gjokaj | Viktor Baskov
(voice) (uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |