| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Capt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| Colin Hanks | Travis Marshall |
| Yasiin Bey | Brother Sam
(as Mos) |
| Edward James Olmos | Prof. James Gellar |
| Geoff Pierson | Deputy Chief Tom Matthews |
| Aimee Garcia | Jamie Batista |
| Molly Parker | Lisa Marshall |
| David Monahan | Nathan Roberts |
| Brea Grant | Ryan Chambers |
| Evan George Kruntchev | Harrison Morgan |
| Luke Andrew Kruntchev | Harrison Morgan |
| Germaine De Leon | Nick |
| Luis Moncada | Julio Benes |
| Justin Huen | Diego |
| Neto DePaula Pimenta | Leo Hernandez |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Kelly Sarah Samuels | Waitress
(uncredited) |