| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Det. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan
(credit only) |
| Geoff Pierson | Capt. Tom Matthews |
| Judith Scott | Lt. Esme Pascal |
| Don McManus | Roger Hicks |
| Jaime Murray | Lila Tournay |
| Keith Carradine | Special Agent Frank Lundy |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Kristen Kerr | Allison |
| Brooks Almy | Caroline |
| Francisco Viana | Det. Jake Simms |
| Tamir Yardenne | Gordon |
| Bjorn Johnson | Leader
(as Bjørn Johnson) |
| Garrett Brawith | Wild Eyed Man |
| Danielle Barbosa | Mother |
| Jay Jackson | Reporter |
| Jeremy Nichols | Anxious Man |
| Martha Hackett | Grieving Widow
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Pablo Soriano | Det. Robert Ramos
(uncredited) |