| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan |
| C.S. Lee | Vince Masuka |
| Christian Camargo | Rudy Cooper |
| Mark Pellegrino | Paul Bennett |
| Dominic Janes | Young Dexter |
| Dakin Matthews | Dr. Pittman |
| Joseph Lyle Taylor | Sgt. McKay |
| Jeanette Miller | Elderly Neighbor |
| Christina Robinson | Astor Bennett |
| Daniel Goldman | Cody Bennett |
| Laura Marano | Young Debra |
| Kathrin Middleton | Doris Morgan
(as Kathrin Lautner Middleton) |
| Winston Story | Messenger |
| Andrew Caple-Shaw | Resident |
| Dion B. Vines | Security Guard
(as Dion Vines) |
| Lance Irwin | Off. Benson |
| Jeff Bullock | Detective
(uncredited) |
| Frank Tedesco | Miami Dade Police Officer
(uncredited) |