| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan |
| Geoff Pierson | Capt. Tom Matthews |
| Sam Trammell | Matt Chambers |
| Rudolf Martin | Carlos Guerrero |
| Cristos | Norberto Cervantez |
| C.S. Lee | Vince Masuka |
| Richard Gunn | Sean |
| Lisa Kaminir | Prosecutor |
| Christina Robinson | Astor Bennett |
| Daniel Goldman | Cody Bennett |
| Maureen Muldoon | Kara Simmons |
| Devon Graye | Teenage Dexter |
| Keith Pillow | Lawyer |
| Brandon Morris | EMT |
| Roger Hewlett | Mr. Pryce |
| Alex Schemmer | Alexander Pryce |
| Andrew Hawkes | Guard |
| Roxanne Beckford | Reporter |
| Nina Onuora | Uniform #1 |
| Camila Banus | Girl Swimming |
| Wing Armstrong | Medical Examiner Munoz
(uncredited) |
| Jason Bartley | Crime Scene Officer
(uncredited) |
| Mike Cochrane | Sasquatch
(uncredited) |
| Parker Cristan | Crime Scene Investigator
(uncredited) |
| Rob Goodman | Dead Victim
(uncredited) |
| Ben Hausbach | Witness
(uncredited) |
| Erik Joseph | Police Officer
(uncredited) |
| Eric Shackelford | Man On Cellphone
(uncredited) |