| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jeanne Tripplehorn | Alex Blake |
| Thomas Gibson | Aaron Hotchner |
| Frederick Koehler | Wallace Hines /
Jesse Gentry
(as Fred Koehler) |
| Camryn Manheim | Carla Hines |
| JoNell Kennedy | Sgt. Lynne Johnson |
| Brianne Howey | Heather Clarke |
| Leah Garland | Dr. Pat Lewis |
| Lauren Denham | Corin Todd
(as Lauren Lee Denham) |
| Robbie Silverman | Mike Hardy
(as Rob Silverman) |
| Katharine Everett | Emma Coleman |
| Brice Williams | Ben Coleman |
| Vince Melocchi | Erik Cole |
| Bianca Malinowski | Mia Rivera |
| Gene Rathswohl | Officer Bachner |
| J. Omar Castro | Cop |
| Ian Bamberg | Waiter |
| Carrie Lazar | Patron |
| D.T. Matias | Mini-Mart Clerk |
| Diane Mizota | Reporter |
| Laura Hunter Drago | Sarah Beck
(uncredited) |
| Kayla Drew | Young Heather
(uncredited) |
| Natalie Lipka | Morphing Woman
(uncredited) |
| Douglas Olsson | Mark Anderson
(uncredited) |