| Joe Mantegna | David Rossi |
| Matthew Gray Gubler | Dr. Spencer Reid
(credit only) |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Aisha Tyler | Dr. Tara Lewis |
| Daniel Henney | Matt Simmons |
| Adam Rodriguez | Luke Alvez |
| Paget Brewster | Emily Prentiss |
| Gale Harold | Dr. Daryl Wright |
| Scott William Winters | Dr. Robert Smith |
| Katie Amanda Keane | Mary Wright |
| Tui Asau | Douglas Knight |
| Paul Bartholomew | Josh Sullivan |
| Brea Bee | Bonnie Sullivan |
| Eric Ramey | M.E. Samuel Bayo |
| Melanie Lewis | Kate Sullivan
(as Melanie Laenani Lewis) |
| Bashir Gavriel | Clay Miller |
| Reid Cox | Molly Witt |
| Ethan Henry | Phil Friedman |
| Aaron Coleman | Keith Brennan |
| Mark Mahoney | Tattoo Artist |
| Sophia Sluyter | Sullivan Kid
(uncredited) |
| Phil Aslaksen | Rehab Patient
(uncredited) |
| Jeff Jocoy | FBI Agent
(uncredited) |