| Joe Mantegna | David Rossi |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Aisha Tyler | Dr. Tara Lewis |
| Daniel Henney | Matt Simmons |
| Adam Rodriguez | Luke Alvez |
| Paget Brewster | Emily Prentiss |
| Brandon Jay McLaren | Captain Adrian Scott |
| Jamie Gray Hyder | Kimberly Desmond |
| Sol Landerman | Gabriel Merza
(as Solomon Shiv) |
| Rose Abdoo | Janel Desmond |
| Kelly Frye | Kristy Simmons |
| Monique Gall | Officer Cenisa Royce |
| Carson Fagerbakke | Gianna Schrader |
| Chinyere Dobson | Becca Miles
(as Chin Yere) |
| Erin Pineda | Lia Wyler |
| Danny Barclay | Curtis Wyler |
| Jim Kane | Phillip Sullivan |
| Ezra Dewey | Jake Simmons |
| Declan Whaley | David Simmons |
| Kaylee Quach | Lily Simmons |
| Genevieve Quach | Chloe Simmons |
| Jamieson Deacy | Girl (Age 10)
(uncredited) |
| Christopher Mark Rodriguez | Dead Police Officer
(uncredited) |