| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish
(credit only) |
| Molly C. Quinn | Alexis Castle |
| Toks Olagundoye | Hayley Shipton |
| Kristoffer Polaha | Caleb Brown |
| Sunkrish Bala | Vikram Singh |
| Arye Gross | M.E. Sidney Perlmutter |
| Rob Brownstein | Captain Ziering |
| Adam Korson | Isaac Dern |
| Dagney Kerr | Sarah |
| Minni Jo | Bethany
(as Minni Jo Mazzola) |
| Scott Michael Morgan | Sam Mackey |
| Annie Abbott | Diane Nelson |
| Helena Barrett | Lara Madden |
| Jorge Borrelli | Salvador Acosta |
| Edith Fields | Sheri Nelson |
| Cantrell Harris | Officer Ellroy |
| Mary Margaret Lewis | Elaine Nelson
(as Mary-Margaret Lewis) |
| Panuvat Anthony Nanakornpanom | Leo Longarzo
(as Anthony Nanakornpanom) |
| Aaron Pont | James |
| Katherine Von Till | Janice Alton
(as Katie Von Till) |
| Leah Mitchell | Dancer
(uncredited) |
| Aubrey Plaza | Lucy
(voice) (uncredited) |
| Tarin Pratt | Dancer
(uncredited) |
| Denna Thomsen | Dancer
(uncredited) |