| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle |
| Penny Johnson Jerald | Captain Victoria Gates |
| Michael Connelly | Michael Connelly |
| Lance Reddick | Keith Kaufman |
| Wallace Langham | Dr. Van Holtzman |
| Cullen Douglas | Noah Lewis |
| Maya Stojan | Tory Ellis |
| Juliana Dever | Jenny Ryan |
| Michelle C. Bonilla | Maxine Collins |
| Mitchell Fink | Paul Gibney |
| Michael Dempsey | Frank Malloy |
| Brian Konowal | Mr. Walters |
| Orestes Arcuni | Administrative Aide |
| Holly Clapham | Nurse |
| Chelsea Gonzalez | Emma Malloy |
| Webb Hayes | 11 Year Old Castle
(as Webb Baker Hayes) |
| Angela Martinez | Reporter |
| Israel Carbajal | Detective at ceremony
(uncredited) |
| Sylvester Foster | Precinct Detective
(uncredited) |
| Schae Harrison | Police Officer Velazquez
(uncredited) |
| Jan M. Janssen | Officer Jenkins
(uncredited) |
| Andrew W. Marlowe | Award ceremony guest
(uncredited) |
| Terri Edda Miller | Award ceremony guest
(uncredited) |
| Julian Reyes | Police Officer at ceremony
(uncredited) |