| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Michael Hyatt | Mrs. Leslie Ruiz |
| Bess Rous | Natalie Barnes |
| Elya Baskin | Sergei Vetotchkin |
| David Barrera | Principal Joe Silva |
| Quinn Friedman | Jason |
| Rachel Eggleston | Emily |
| Laura Kai Chen | Detective Miranda Daniels |
| Aleksandra Kaniak | Katerina Vetotchkin |
| Juan Gabriel Pareja | Greg Maxwell |
| Kai Scott | Jack |
| Suzanne Sena | Emily's Mom |
| Kyla-Drew | Sophie
(as Kyla-Drew Simmons) |
| Cliff Simon | Polkovnik
(as Cliff Marc Simon) |
| Terri Douglas | (voice) |