| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Christopher Cousins | Nolan Burns |
| James MacDonald | Benjamin Wade |
| Erik Jensen | Professor Jason Byford |
| Aaron Craven | Henry Collins |
| Jeff Odachowski | Kenny (Swordsman)
(as Jeffrey Odachowski) |
| Daniel Edward Mora | Silas Mora |
| Myko Olivier | Pi |
| Pamela Shaddock | Marcella |
| Kaylen Davidson | Susannah
(uncredited) |
| Rob S. Gray | Crackhead
(uncredited) |
| Sarah Molasky | Susannah Richland
(uncredited) |
| Jordann Zbylski | Female Victim
(uncredited) |