| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Darby Stanchfield | Meredith |
| Mark Deklin | Corey Francis /
Noah Kesswood |
| Jack Wagner | Billy Piper |
| Nancy Lee Grahn | Samantha Voss |
| Victoria Pratt | Jane Garrison /
Leann Piper |
| Allan Wasserman | Samuel Schuster |
| Deji LaRay | Herman Poquille |
| Adrian LaTourelle | Robert Garrison |
| Stephanie Drapeau | Michelle Twohey |
| Brendan Ford | Walter Voss |
| Nathan Pelle | Aaron |